Surface Treatment Technology Using Ultrashort Pulse Lasers Could Help Treat Heart Failure

Hierarchical Surface Restructuring technology can be used to enhance charge storage capacity, increase specific capacitance, & decrease impedance of electrodes & microelectrodes.

Daphne Allen

June 29, 2022

2 Min Read
Optical and SEM micrographs of hierarchically restructured electrodes for various neural interfacing applications: a) a cylindrical Ti electrode; b) a helix Pt-10Ir electrode for cardiac pacing applications; c) a rivet-style Pt-10Ir electrode for an electrophysiology mapping catheter; and d) a cylindrical Pt10Ir electrode for use in a percutaneous spinal cord stimulation electrode array. Image and caption courtesy of Pulse Technologies Inc.Image courtesy of Pulse Technologies Inc.

A novel surface modification technology is helping a medtech company develop a new solution for treating heart failure.

Cardionomic Inc. is developing the Cardiac Pulmonary Nerve Stimulation (CPNS) System for treating patients suffering from Acute Decompensated Heart Failure (ADHF). Currently an investigational device in the United States, CPNS is designed to increase contractility of the heart to pump more blood to the rest of the body, according to the company.

To develop the device, Cardionomic has employed Hierarchical Surface Restructuring (HSR) technology from Pulse Technologies Inc., according to Steve Goedeke, CEO of Cardionomic.  

HSR is an advanced surface treatment technology that can be used to modify the surface of implantable electrodes and microelectrode arrays using ultrashort pulse lasers, Shahram Amini, PhD, director of R&D for Pulse Technologies, told Design News. “The primary intent is to increase the electrode surface area to improve and tune electrochemical performance of the device,” he explained. Its impact on electrochemical performance could help enhance charge storage capacity, increase specific capacitance, and decrease impedance.

It is different from other surface treatments in that HSR truly modifies surfaces. “Most other treatments are additive coatings,” Amini said. “Coatings can be subject to cracking, flaking, delamination, and spallation. HSR by contrast is tunable, providing a truly engineered surface morphology.”

HSR may enable “miniaturization of electrodes and microelectrode arrays by increasing electrochemical surface area,” as it can support production of “smaller electrodes with enhanced electrochemical performance, durability, selectivity, and resolution,” Amini explained. “More importantly, through our enabling of more efficient electrodes through this process, the battery life of active implantable devices can be extended.”

Potential applications for HSR include neuromodulation, cardiac rhythm management, electrophysiology mapping catheters, and cochlear implants, Amini said. And “some new applications we are investigating are in the diagnostic area and in the area of industrial seals,” he added. 

Pulse began development and initial commercialization of HSR just over 5 years ago, Amini said. “As awareness of this technology grows, various customers from different industries contact Pulse to push the boundaries of HSR capabilities. Through research and development projects even Pulse continues to gain an understanding of the versatile value it can provide in seemingly limitless applications,” he said.

About the Author(s)

Daphne Allen

Daphne Allen is editor-in-chief of Design News. She previously served as editor-in-chief of MD+DI and of Pharmaceutical & Medical Packaging News and also served as an editor for Packaging Digest. Daphne has covered design, manufacturing, materials, packaging, labeling, and regulatory issues for more than 20 years. She has also presented on these topics in several webinars and conferences, most recently discussing design and engineering trends at IME West 2024 and leading an Industry ShopTalk discussion during the show on artificial intelligence.

Follow Daphne on X at @daphneallen and reach her at [email protected].

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