Chad Mirkin is developing a new DNA detection method. The Northwestern University professor and director of the school's Institute of NanoTechnology pairs microelectrodes and nanoprobes for detecting Anthrax, small pox, and other biohazards. He asserts that nanotechnology offers better results in all categories of detection, including sensitivity, selectivity, cost, ease of use, and speed. The new detection method eliminates the need to heat the gene chip. Mirkin says that companies in the gene chip technology business currently use a polymerase chain reaction (PCR) for detection. Gene chips are read using a confocal microscope, a complex instrument costing more than $60,000. Mirkin's electrical DNA detection method eliminates the PCR. It also allows testing of thousands of biological targets on a single chip. Various DNA tests are placed on a glass slide, each made up of single strands of synthesized DNA that bind with targeted DNA. The bound strands are placed between a pair of electrodes, one test for each pair. When the slide is placed in a solution containing the target, perfect and partial matches bind to gold probes. The probe accumulations are then amplified using modified photographic developing solution. Each gold nanoparticle becomes covered with silver and grows in size, closing the gap between the electrodes and thus carrying a current. For more information, go to www.northwestern.edu.
Using wireless chips and accessories, engineers can now extract data from the unlikeliest of places -- pumps, motors, bridges, conveyors, refineries, cooling towers, parking garages, down-hole drills and just about anything else that can benefit from monitoring.
With strong marketplace demand for qualified engineers across the board that currently outstrips the available supply, there may never be a better time for engineers and project managers to advance their careers and salaries. Whether those moves are successful in the short-term and long-term is likely to depend on how the transition from one job to the next is handled.
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