HOME  |  NEWS  |  BLOGS  |  MESSAGES  |  FEATURES  |  VIDEOS  |  WEBINARS  |  INDUSTRIES  |  FOCUS ON FUNDAMENTALS
  |  REGISTER  |  LOGIN  |  HELP
Blogs
Engineering Materials

Bone Repair Aided by Silk Scaffold

NO RATINGS
1 saves
View Comments: Oldest First|Newest First|Threaded View
Page 1/2  >  >>
gsmith120
User Rank
Platinum
Interesting Research on Bone Repair
gsmith120   5/22/2012 8:24:14 AM
NO RATINGS
Ann, very interesting story.  Is this technology being used on real patience or it is still in the development stages?    I hope you will write future stories on this as it continues to develop.

williamlweaver
User Rank
Platinum
Biodegradable Drug Delivery
williamlweaver   5/22/2012 8:24:19 AM
NO RATINGS
Wow, Ann! This is fantastic. I've worked with Poly(methyl methacrylate) (PMMA) bone cement along with researchers here at the Einstein Medical Center here in Philadelphia. Our research was investigating the mechanical properties (strength) of PMMA after having chemotherapeutic agents mixed in with the monomer before polymerization and the elution rates of the drugs after they were placed in vivo. The PMMA retained its strength for the most part, but the slow elution rates of most drugs meant a patient would have to endure low dose chemo drugs over many years to decades. 

A biodegradable bone scaffold material such as this could be used to deliver the chemo drugs over a finite amount of time. Promising applications...


naperlou
User Rank
Blogger
Natural materials
naperlou   5/22/2012 9:17:20 AM
NO RATINGS
Ann, this seems like a good example of natural based materials being used to solve a human health problem.  Is that the case? 

Ann R. Thryft
User Rank
Blogger
Re: Interesting Research on Bone Repair
Ann R. Thryft   5/22/2012 12:00:55 PM
NO RATINGS
gsmith, I doubt if this has been used on actual patients yet--this is an R&D project at a university, and the announcement would most likely have mentioned any beta testing. If we hear anything about actual testing, I'll be happy to report on it.

Ann R. Thryft
User Rank
Blogger
Re: Biodegradable Drug Delivery
Ann R. Thryft   5/22/2012 12:02:17 PM
williamlweaver, thanks for the enthusiastic response from someone who's worked with materials aimed at similar applications. The scenario you mention sounds very similar to the idea the Tufts researchers mention, of drug delivery over a short period, and then the scaffold biodegrading in situ.

Rob Spiegel
User Rank
Blogger
Re: Interesting Research on Bone Repair
Rob Spiegel   5/22/2012 3:43:24 PM
NO RATINGS
This is an exciting development, Ann. The biomedical field is just going to get more and more interesting in coming years. If this material could help those with osteoporosis, it could have a major impact of the quality of life for millions.

Ann R. Thryft
User Rank
Blogger
Re: Natural materials
Ann R. Thryft   5/22/2012 3:55:49 PM
NO RATINGS
naperlou, I think you're right. This is yet another case of using natural materials to solve problems by taking advantage of their inherent characteristics, instead of trying to force synthetic materials to do something they are not made to do, or can't easily do (be bio-compatible and biodegradable, in this instance). Of course, the researchers had to design silk matrices to mimic bone, but that apparently wasn't too tough to achieve.

NadineJ
User Rank
Platinum
Re: Natural materials
NadineJ   5/22/2012 11:49:40 PM
NO RATINGS
Nice article.  I suspect this can be vegan friendly since long silk strands aren't needed. 

Ann, do you know if the silk can be harvested after the moth emerges for this?  Boiling larvae alive is generally how long silk threads are extracted.

Many true vegans, whether for ethical or religious reasons, have difficulties with many medical procedures because of animal material or testing used.

Personally, i love to see biomimicry in new developments.

TJ McDermott
User Rank
Blogger
Permanent?
TJ McDermott   5/23/2012 3:22:09 AM
NO RATINGS
Ann, does this "scaffold" become a permanent part of the bone, or will it eventually be removed from one's body?

Ann R. Thryft
User Rank
Blogger
Re: Interesting Research on Bone Repair
Ann R. Thryft   5/23/2012 12:44:28 PM
NO RATINGS
Thanks, Rob, I agree. I was really happy to see this. I especially like the cross-application aspect: silk has been used for years in sutures because it's biocompatible and biodegradable.

Page 1/2  >  >>
Partner Zone
More Blogs from Engineering Materials
Many of the new adhesives we're featuring in this slideshow are for use in automotive and other transportation applications. The rest of these new products are for a wide variety of applications including aviation, aerospace, electrical motors, electronics, industrial, and semiconductors.
A Columbia University team working on molecular-scale nano-robots with moving parts has run into wear-and-tear issues. They've become the first team to observe in detail and quantify this process, and are devising coping strategies by observing how living cells prevent aging.
Many of the new materials on display at MD&M West were developed to be strong, tough replacements for metal parts in different kinds of medical equipment: IV poles, connectors for medical devices, medical device trays, and torque-applying instruments for orthopedic surgery. Others are made for close contact with patients.
New sensor technology integrates sensors, traces, and electronics into a smart fabric for wearables that measures more dimensions -- force, location, size, twist, bend, stretch, and motion -- and displays data in 3D maps.
As we saw on the show floor this week at the Pacific Design & Manufacturing and co-located events in Anaheim, Calif., 3D printing is contributing to distributed manufacturing and being reinvented by engineers for their own needs. Meanwhile, new fasteners are appearing for wearable consumer and medical devices and Baxter Robot has another software upgrade.
Design News Webinar Series
2/25/2015 11:00 a.m. California / 2:00 p.m. New York
12/11/2014 8:00 a.m. California / 11:00 a.m. New York
12/10/2014 8:00 a.m. California / 11:00 a.m. New York
11/19/2014 11:00 a.m. California / 2:00 p.m. New York
Quick Poll
The Continuing Education Center offers engineers an entirely new way to get the education they need to formulate next-generation solutions.
Feb 23 - 27, Baremetal C Programming for Embedded Systems
SEMESTERS: 1  |  2  |  3  |  4  |  5  |  67


Focus on Fundamentals consists of 45-minute on-line classes that cover a host of technologies. You learn without leaving the comfort of your desk. All classes are taught by subject-matter experts and all are archived. So if you can't attend live, attend at your convenience.
Learn More   |   Login   |   Archived Classes
Twitter Feed
Design News Twitter Feed
Like Us on Facebook

Sponsored Content

Technology Marketplace

Copyright © 2015 UBM Canon, A UBM company, All rights reserved. Privacy Policy | Terms of Service