When Mae West pronounced that too much of a good thing sometimes is a good thing, she probably didn't have the versatile molecule nitric oxide (NO) in mind. However, biologists at Washington University (St. Louis) have shown that a high concentration of NO in osteoclast bone cells might keep them from eating away too much bone, preventing bone loss associated with such diseases as osteoporosis. A team led by Philip Osdoby, a professor of biology, introduced an antibody into the osteoclasts that halted bone resorption, a process where bone is gnawed away by osteoclasts that are too numerous or too active. Biochemical tests showed that, after adding the antibody, an increase in NO occurred, followed by decreases in bone resorption. Osdoby believes that NO acts as a signal to turn the osteoclast off. "With a better understanding of how NO is regulated in osteoclasts, we may be able to develop new strategies to prevent bone loss," Osdoby adds. E-mail Susan_Killenberg@aismail.wustl.edu .
Samsung's Galaxy line of smartphones used to fare quite well in the repairability department, but last year's flagship S5 model took a tumble, scoring a meh-inducing 5/10. Will the newly redesigned S6 lead us back into star-studded territory, or will we sink further into the depths of a repairability black hole?
In 2003, the world contained just over 500 million Internet-connected devices. By 2010, this figure had risen to 12.5 billion connected objects, almost six devices per individual with access to the Internet. Now, as we move into 2015, the number of connected 'things' is expected to reach 25 billion, ultimately edging toward 50 billion by the end of the decade.
NASA engineer Brian Trease studied abroad in Japan as a high school student and used to fold fast-food wrappers into cranes using origami techniques he learned in library books. Inspired by this, he began to imagine that origami could be applied to building spacecraft components, particularly solar panels that could one day send solar power from space to be used on earth.
Biomedical engineering is one of the fastest growing engineering fields; from medical devices and pharmaceuticals to more cutting-edge areas like tissue, genetic, and neural engineering, US biomedical engineers (BMEs) boast salaries nearly double the annual mean wage and have faster than average job growth.
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